In this interview, Vicki Kirby discusses her research into the relationship between nature and culture, focusing in particular on her recent edited collection, What If Culture Was Nature All Along? The volume appears in the ‘New Materialisms’ series, and so the interview begins by situating the collection with respect to the recent materialist turn in social theory. Kirby discusses the influence of deconstruction on her thought, and the way that she draws upon Derrida to think through recent research in the life sciences and its implications for understanding the relationship between matter, life, and communication. She also goes into the political implications of her work and the relationship between biopolitics and biodeconstruction.